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ARCHIVE:  February 27, 2002

5-methoxy-N-ethyl-N-isopropyltryptamine, 5-MeO-MIPT, 5-MeO-DIPT, 5-MeO-EIPT

Dear Dr. Shulgin:

A company that sells chemical novelties has recently begun selling something that they call 5-methoxy-N-ethyl-N-isopropyltryptamine. I have searched the Internet, TIHKAL, and other literature for it. I can't find mention of it anywhere. Is it psychoactive? If so what are the effects and what's the dose range?

-- Derek


Dear Derek:

I must admit that I am a total stranger to that compound. And I made a quick search on line of the last few decades of Chemical Abstracts and it is just possible that it is not even in the scientific literature.  

The same compound with one fewer carbon atoms, the N-methyl-N-isopropyl homologue I synthesized many years ago, and called it 5-MeO-MIPT. It is indeed in TIHKAL and I have reported it to be active in the 4-6 milligram range, orally. And the same compound with one additional carbon atom, the N,N-diisopropyl homologue, is also an old friend which I had named 5-MeO-DIPT. In TIHKAL its dose is suggested to be in the 6-12 milligram range. But the N-ethyl is half-way between those two compounds and I never did get around to making it.

But apparently someone else did. My gut feeling would be to call it 5-MeO-EIPT. But as to predicting the active dosage range and its effects, I would be conservative and cautious. I have been caught more than once with the easy logic of, "Since this is half way between A and B as to structure, it will probably be half way between them in potency as well." Every new compound is a unique entity and must be approached as the total unknown that it is. Start small. Give time between trials. And in something that is publicly available, learn everything you can from other explorers.

-- Dr. Shulgin

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