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Making MDA, MDEA &
Dear Dr. Shulgin:
have been many rumors about MDA, MDEA and MDMA, mainly saying that one is harder to make
than another. I would like to know if this is so, as far as synthesis and precursors
are concerned. Thanks in advance. -- Chris
The usual precursor for all three
of these drugs is a simple compound, piperonylacetone. This is made from the
essential oil safrole, usually by way of the intermediate isosafrole.
All three compounds are equally easy to make by reductive amination, calling upon ammonia
for MDA (methylenedioxyamphetamine), methylamine for MDMA
(methylenedioxymethamphetamine or N-methyl-methylenedioxyamphetamine), and ethylamine for
MDEA (N-ethylmethylenedioxyamphetamine). The amount of product obtained is quite
variable, however, with MDA usually being produced in the lowest yield.
Do bear in mind that although these
chemical conversions are quite straightforward, they are felonious actions and the
preparation of any one of these three compounds is a prosecutable crime. One of the
major causes of damage resulting from the exploration of these areas is that one
encounters, not scientific, but legal problems.
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